Hyperhydration to Improve Kidney Outcomes in Children with Shiga Toxin-Producing E. Coli (HIKO STEC) – NEW PUBLICATION

This planning study will allow us to finalize RCT design, outcome measures, eligibility criteria, intervention and control arms, sample size, analysis plan and the preparation of study related materials. The CDC estimates that in the U.S., each year, over 175,000 individuals are infected by Shiga toxin-producing Escherichia coli (STEC). A complication of STEC infections is the hemolytic uremic syndrome (HUS). Preliminary data indicates that early volume expansion prior to the development of HUS can mitigate the complications of HUS.